The Diocese was established by the enthronement of Bishop Karas by the hands of Pope Tawadros II on November 11, 2017.
His Grace Bishop Karas is the Bishop of the Diocese of Pennsylvania And Affiliated Regions to currently include the states of Pennsylvania, Delaware, Maryland, and West Virginia. The number of churches by the state in this Diocese is below:
- Pennsylvania (12)
- Delaware (1)
- Maryland (3)
- West Virginia (1)